Ooh! "The Rabbi's Cat" by Joann Sfar. It would be fun to discuss in a class--it's got lots of historical and philosophical type stuff in it.

Any syllabus of graphic novels would be pretty poor if it didn't include at least 1/3 translated manga/manhwa. I have nothing against Drowtales, there might be other good reasons to recommend it, just wanted to point out that the points you mentioned aren't important if you're already got a healthy selection of real manga.I'm considering suggesting Drowtales: Moonless Age, it's written in English, and left to right, but it has the manga style of exaggerating emotions.