It's what makes publisher rejections so frustrating, when all they say is: we're not interested at this time. An even brief explanation could help me understand if the problem with my story is simply that it doesn't have a good hook, or if the problems are far greater than that. I know I'm struggling with giving my story a hook, despite how much I've brain stormed how to do so.
I feel your pain. The problem with agents and publishers is that they get so many submissions that they only have a few minutes to assess your work, and so they judge it much like a reader would if they picked up your book in a store for the first time. They look for a good hook and read the opening paragraphs, and base their decision on that. Your book could be amazing, but if the opening is weak or a little cliched and there isn't a strong enough hook, they probably will never discover the gem that is hidden further inside.
Often the marketing department can override an editor when it comes to their decision on whether to purchase a novel or not, which is exactly why one of my novels was rejected. Instead of following the usual 3 act structure- inciting incident, confrontation, resolution, I went with a more of a "Lost" structure, where the characters are thrown into a strange situation that unfolds (and only makes sense) over the length of the novel. Unfortunately I was told that, without a high concept they simply didn't know how to market it.
Fortunately your writing is an asset and usually doesn't have an expiration date, so it doesn't matter if you have to tuck the novel away for a season and bring it out once you have built relationships in the industry who are then willing to give it a fair chance, but forcing a hook where there isn't one can break your story, and come of as contrived.
Consider what your beta readers have to say, but don't second guess yourself if they like it and publishers don't.
And if you get some distance from it and come back in a few months and decide your story is great as it is, then you can always consider self publishing.
As a side note, there are also companies that will look at your work with a critical eye and offer valuable feedback. Just do a search on Absolute Write and you should find something. hell, I'm sure you could pay most freelance editors to do that.
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