I've been following Joss' work religiously for 15 years now, so I won't be much use for criticism. I'm in for the awesome!
Lots of small stuff that made me laugh out loud - the truth serum scene, the cosplay joke, Agent Hills's drawing that totally wasn't poop with knives sticking out. Because it was a pilot, they didn't go deep into much yet, and we've yet to see about half of the team to really register as characters, but I trust the Whedons to make that work over the season - team shows have always been one of Joss' strengths.
That said, I couldn't help but notice most of the characters reminded me of ones he wrote before. There's a lot of Kayleigh in Simmons, some Topher in Fitz, quite a bit of Caroline in Skye and so on. So, as the characters emerge, they won't just have each other to grow distinguishable from.
For the near future, I'm hoping they won't stick solely to the Centipede thing and make it more of a spy show. But I'm also hoping for more Cobie Smulders, and that doesn't look likely. So I'll be okay whatever they come up with.