My wife and I received a pleasant request for the first three chapters of our latest YA novel -- and a request that the ms. be exclusive to Pippin for one month. With the manuscript already out to other agents, we couldn't grant the exclusive. I assume this was a deal-killer since we haven't heard from the agent since we shared that info.
I would try and double-check before declaring it a deal-killer. Not being able to grant an exclusive isn't an automatic not interested with agents - it differs from one agent to the next. Some will still consider it, some won't. But I'd be sure first.