Werewolves seem the most difficult to keep fresh. They're just mindless animals that snarl and growl and chase you. Unless they're contagious, in which case there's the added horror that you'll turn into one, but the same threat is presented with a fast moving zombie. Or you got your demented werewolves that are evil even as in human form, which basically just gives a shape shifting serial killer.
If you go down the werewolves-as-horror route, part of it is the horror of
being the werewolf. You black out and then wake up, covered in blood. WHo did you kill? You can't control it, you hurt people. "Even a man who prays every night is a demon under the full moon's light" and all that. It's hard to sustain that horror overly long, but that's the sympathetic terror part and the traditional horror elements.
Another element is that you don't know
who the werewolf is. It could be anyone. And the werewolf may not even know it. There may not even be a way to "test" people. So you have paranoia.
One way to use this is to have a group of characters stuck in a small location. There's a werewolf among them, they know it, and the full moon is scheduled for that night. Suddenly you have a ticking clock until the werewolf bursts out and kills everyone. What do they do? The horror here is the slowly approaching imminent death, the panic to avoid it, and the paranoia of who's the werewolf.
Finally, the werewolf offers the opportunity to do something you don't see a lot in "big monster that eats everyone" stories: it could be intelligent. Rather than a crazy feral beast, it could have cunning and the ability to plan. It could destroy vehicles or firearms, knowing they're a threat. It could use lures, fakeouts, misdirection, it could herd people towards a dead-end. Suddenly it's not just another monster, but the alien from
Predator without technology: it wants to Hunt you. To separate this from the "demented shapeshifting serial killer", the werewolf is only like this when it's wolfed out. This way the human doesn't know it, it can't shift back and forth, and it's not going to say, build traps or work locks.