I think Roxx and others bring up very good points that we need to keep in mind when beta-reading (and mining the nuggets from our beta-reader advice). I know since joining AW, and even before with an IRL beta-reader I have who is a fellow author, that fellow writers may gnash their teeth over things that your average Joe reader (or your intended audience) just doesn't care about. If it's good story that keeps them turning the page and they love to love or hate your characters, well...hey, you're on to something! So I try to test some suggestions back on my "Book Club Beta-Readers" before I do anything drastic.
As far as other annoyances, I hate when sex derails a character's development cycle. (And I'm looking at Ms. Hamilton on this one - I still grit my teeth at what happened to Anita Blake, vampire hunter extraordinaire.) I think it bothers me when the MC, whether it's male or female, becomes defined by sex rather than by their other actions (unless you're reading erotica, which is a different kettle of fish). It's a copout, and it makes me sad when a great character's knee jerk reaction is to solve it through the bedroom, rather than relying on brains or other kick-ass actions. Come on, if he's a jerk, just punch his lights out, right? Do you really need to seduce him? But I'm starting to digress into a rant...(and yeah, I do like romance, despite how this may read).