Sat Nam! (literally "Truth Name"--a Sikh greeting)
The agency Dystel & Goderich specifically states on the website to double space everything except the query letter. And they ask for a synopsis. So, go with what the agent says on the website. For those who say nothing, the default seems to be single spaced, but I doubt any would throw it out for double spacing.
Blessings,
Siri Kirpal