Many things will earn an almost automatic reject. Queries that aren't attached to actual books, but of the, "Hi, I'm a writer!" variety. The category I like to call "insane." Anything that mentions Oprah's book club, promises me fame and fortune, or claims that Hollywood will come knocking. These are never connected with good writing.Are there things that bother you in queries or rub you the wrong way?
Similarly, I can't believe how many queries are semi-literate. I'm not just talking about careless typos (although this is an invariably poor sign, too), but where the writer doesn't understand basic grammar, spelling, or punctuation. Nobody would ever dream of putting on a Knicks' uniform and trotting onto center court at Madison Square Garden, expecting to start in an NBA game, but completely unprepared people try this sort of thing all the time with writing.
But none of those things really bother me, so much as make me either shake my head or feel a little sorry for the writer.
What does bother me is unearned familiarity. I'm not so much a stickler that it bothers me when you call me Michael, instead of Mr. Carr, but I can't understand why people sometimes call me dude, buddy, friend, man, or any one of a number of other strangely familiar greetings. About once a day someone will call me Mike in their query letter.
It doesn't make me angry in real life when someone calls me Mike, but my good friends never do. My family doesn't, my wife doesn't. I've never in my life introduced myself as Mike and don't think of myself as Mike. As an agent, my name does not appear anywhere as Mike, so I can't figure out why someone would call me that unless they've made an assumption and are trying to force a familiarity that doesn't exist. This tactic does not work.
ETA: If we've already corresponded, please do call me Michael instead of Mr. Carr. That's perfectly acceptable. Preferable, in fact.