Being a short story writer by nature, I tend to enjoy writing Prologue's, because I just turn them into little self-contained stories. Honestly, I have no problem with them.
I think when it comes time to edit, they're just another darling that is at risk of being killed, no more or less likely than any of the rest of your manuscript. I'm not sure I entirely understand why one would skip the prologue when reading. It's sort of like skipping over Chapter 13, because it's unlucky.
When I'm reading, I'm more or less an open-slate. The author wants me to enjoy something to feel something, to think something, and I'm happily willing to do all those things. By and large, I assume the author is a professional up till the point in the book when I realize he's not. By this assumption, if the author has a prologue, then I shall read his prologue.
But then, I read my books cover-to-cover. I especially delight in "Author's Words/Foreword/Afterword/Acknowledgements/etc." because love hearing author's talk. So if I'm reading your book, then anything between the covers is going to get read.
Maybe that's just me.