Re: re:rules
If your book is sufficiently brilliant you could write it with your finger on brown paper bags using warm spit.
If your book is less brilliant, sticking with standard manuscript format is a better bet.
I've had the privilege of seeing raw submission manuscripts by some of the very top best selling authors.
With one or two Notably Irascible Exceptions they all used absolutely standard format: Courier type, one-inch margins, double space, black ink on white 8x10 paper, running header, underline for italics, double underline for boldface.