For each thing in a submitted novel that presents a challenge towards publication, your writing, story, and characters have to be all the more amazing for the agent/publisher to take it on and work with you with the potential problems.
As an example:
Let's assume you have an amazing query that absolutely hooks an agent, and they're excited to read all ten of the pages you included with the hope of requesting a full from you.
But you write in a tense that they don't love. It's okay. They can live with that. Many of their authors use that tense. It's not an auto-reject, just a point against.
Also, the first sentence has the POV character waking up. Sigh, that's the 57th one today. But that's easily edited (if they don't decide the wake-up was warranted), and they're still hopeful enough for the book because your pitch sounded so interesting.
Shoot, now the character's launching into an "As You Know, Bob" infodump that lasts for 5 of your 10 pages. When does the exciting stuff come in(?), the agent wonders.
Now that they're able to be distracted from the story enough to notice your sentence structure, these sentences are awfully wordy. You had a high/low/perfect word count and that could affect how the agent feels about the overwriting.
And there's quite a few grammar mistakes, too. You know what, the agent decides, this book is going to be too much work. Pass.
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You can't do anything about agent's preferences in tense (or, like, if they hate stories that include cats, and a cat is a major plot point of your book, or whatever preferences a single agent might have), and sometimes you need to include things that are advised against because it is right for your novel. Those things are somewhat out of your control. So you do all the things that are within your control to make the book stand out in a good way, not a bad way. You polish it to the absolute best of your ability, then you get some impartial eyes on it to give you their thoughts, which you are free to use or ignore as is best for your novel, and you polish it up even more, and then when you feel you've done everything you can to anticipate potential problems and fix any that are fixable, that's when you take a risk on sending it out.